Discussion on the antiseptic effect of benzoic aci

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Discussion on the preservative effect of benzoic acid and sodium benzoate in meat products (Part I)

scientific? This paper introduces the physical and chemical properties, preservative mechanism, toxicity test and detoxification mechanism in human body of benzoic acid and sodium benzoate, as well as the use of these two preservatives abroad, in order to provide a reference basis for discussing whether benzoic acid and sodium benzoate can be added and used in meat products

1. benzoic acid and sodium benzoate

at present, sodium benzoate and potassium sorbate are mainly used as food preservatives in China. Because sodium benzoate is cheap, it is widely used by food enterprises

physicochemical properties (wansuying, 1998; Ling Guanting, 2003):


molecular formula: chcooh

structural formula:

also known as benzoic acid, odorless or slightly fragrant, widely used as a food preservative. It naturally exists in cranberries, prunes, cinnamon, cloves, and is an aromatic acid, It can also be added as a spice. Undivided acid has antibacterial activity, and it has the best activity in the range of pH 2.5-4.0. Toxicological basis: oral administration of 2530mg.kg-1 (BW) 50grasfda-21cfr184.1021adi0-5mg.kg-1 (BW) (total amount of benzoic acid and its salts, calculated by benzoic acid) (FAO/who, 1994) sodium benzoate Molecular formula: chcoona structural formula:

is the sodium salt of benzoic acid, odorless or slightly fragrant, which can be partially converted into active benzoic acid in acidic food. The anti-corrosion mechanism is the same as that of benzoic acid. It is more commonly used than benzoic acid because it is more soluble in water than benzoic acid, is stable in the air, and has a strong inhibitory effect on yeast and bacteria. Toxicological basis: oral administration of 4070mg.kg-1 (BW)

50grasfda-21cfr184.23 to LD rats, 181.733

adi0-5mg.kg-1 (BW) (the total amount of benzoic acid and its salts, calculated by benzoic acid) (FAO/who, 1994)

anti corrosion mechanism: benzoic acid preservatives act with their undissociated molecules. Undissociated benzoic acid has strong lipophilicity and is easy to pass through the cell membrane and enter the cell, It interferes with the permeability of microbial cell membranes such as molds and bacteria, hinders the absorption of amino acids by cell membranes, enters the benzoic acid molecules in cells, acidifies the alkali storage in cells, inhibits the activity of respiratory enzymes in microbial cells, and thus plays a preservative role (Hou Zhenjian, 2004)

benzoic acid is a broad-spectrum anti microbial reagent, which can also provide various equipment information for yeast, mold and some bacteria. It has a good effect on all kinds of bacteria within the maximum allowable range of use and below pH 4.5

toxicity and safety: in order to ensure the absolute safe use of food additives, countries all over the world have strict regulations on the use, scope of application and maximum amount of various food additives, which are subject to regulations and laws. Internationally recognized safety indicators of food additives include LD, 50

gras and Adi (Ling Guanting, 2003). LD (rat, oral) is a commonly used indicator to judge the safety of food additives, and it is also the first stage of acute toxicity test indicators in toxicological evaluation that any food additive must carry out. The larger LD indicates the smaller toxicity, The higher its safety is when it is used in food. According to the toxicity classification regulations of the toxicological evaluation standard for food safety (1994) issued by the Ministry of health, benzoic acid and sodium benzoate belong to the actual non-toxic category. After repeated experiments and customer verification, sodium nitrite, which is commonly used as a chromogenic agent in meat products, has a LD of 220mg.kg-1, belonging to the medium toxic category

GRA2. Poor jaw quality s is a safety index for FDA to evaluate food additives. According to FDA regulations, benzoic acid (FDA, § 184.10212000) is listed as a generally recognized safe food additive (GRAS). ADI (acceptabledailyintakes) value is the number of milligrams per kilogram of body weight per day. The value is stipulated by FAO/who (1994). The amount of benzoic acid used in food is 0.2-1g/kg. As long as it is used according to the addition amount specified in the national standard, there will be no safety problems

human detoxification mechanism: when a small amount of benzoic acid is added to food, it is not toxic to human body. The application and toxicity tests in the world for many years show that benzoic acid has no cumulative, carcinogenic, teratogenic, mutagenic and antigenic effects if added at 0.06g/kg. Benzoic acid can be quickly absorbed in the body. Benzoic acid will combine with glycine to form hippuric acid (Glycine benzoyl), as shown in Figure 1. The rest will combine with glucuronic acid to form 1-benzoyl glucuronic acid. 75-80% benzoic acid is discharged from the human body within 6 hours, and all of it can be discharged from the body after 10-14 hours

(FAO, 1974). This detoxification effect makes benzoic acid not accumulate in the body when conducting zigzag experiments on metal materials such as steel plates, ribbed steel, round steel, and just welded parts. It should be noted that cats are sensitive to benzoic acid and should be paid attention to when producing pet food. Feeding cats with meat containing 2.39% benzoic acid, 17 of the 28 cats showed nervousness, excitement, loss of balance and vision (FAO, 1974)

(to be continued)

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